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Cancer: Gastric (Stomach) Cancer

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Woman diagnoses her own ovarian cancer with Google search
Sadie Rance turns to internet search engine for answers after being told stomach pains and constipation were due to Irritable Bowel Syndrome
Source: Telegraph Health - February 6, 2015 Category: Consumer Health News Tags: search ovarian Irritable Bowel Syndrome Sadie Rance diagnosed Cancer Google Source Type: news

Identifying and Describing the Impact of Cyclone, Storm and Flood Related Disasters on Treatment Management, Care and Exacerbations of Non-communicable Diseases and the Implications for Public Health
Conclusion Cyclone, flood and storm related disasters impact on treatment management and overall care for people with NCDs. This results in an increased risk of exacerbation of illness or even death. The interruption may be caused by a range of factors, such as damaged transport routes, reduced health services, loss of power and evacuations. The health impact varies according to the NCD. For people with chronic respiratory diseases, a disaster increases the risk of acute exacerbation. Meanwhile, for people with cancer, cardiovascular diseases and diabetes there is an increased risk of their illness exacerbating, which can ...
Source: PLOS Currents Disasters - September 28, 2015 Category: Global & Universal Authors: jc164421 Source Type: research

The Prognostic and Clinical Value of CD44 in Colorectal Cancer: A Meta-Analysis
Conclusions: This meta-analysis demonstrated that CD44 overexpression might be an unfavorable prognostic factor for CRC patients and could be used to predict poor differentiation, lymph node metastasis and distant metastasis. Introduction Although therapies for colorectal cancer (CRC) has improved in recent years, colorectal cancer is still the third most common cause of cancer related death worldwide (1). Metastasis are observed in 25% of patients at initial diagnosis and approximately 50% of patients will develop metastasis (2). Presently, the outcome prediction and the therapy schedule determination of CRC patie...
Source: Frontiers in Oncology - April 29, 2019 Category: Cancer & Oncology Source Type: research

Search for potential Inducible Nitric Oxide Synthase inhibitors with favorable ADMET profiles for the therapy of Helicobacter pylori infections.
CONCLUSION: The top-ranked compounds from the virtual screening workflow show promising results regarding the iNOS inhibition profile. The results evidenced the importance of the ionic bonding during docking selection, playing a crucial role in binding and positioning during ligand-target selection for iNOS. PMID: 31721712 [PubMed - as supplied by publisher]
Source: Current Topics in Medicinal Chemistry - November 10, 2019 Category: Chemistry Authors: Rodrigues RP, Ardisson JS, Ribeiro Gonçalves RC, Oliveira TB, Barreto da Silva V, Kawano DF, Kitagawa RR Tags: Curr Top Med Chem Source Type: research

Cellular mesenchymal epithelial transition (C-MET) gene copy number variation in gastric adenocarcinoma: A pilot search for new marker for targeted therapy in HER-2/neu resistance.
Abstract Increasing HER-2/neu resistance in gastric carcinoma has encouraged search for new biomarkers for targeted therapy. Cellular mesenchymal epithelial transition (C-MET) is one such tyrosine kinase inhibitor proposed for personalized salvage treatment. We determined frequency of C-MET gene copy number variation (CNV) by Fluorescent in-situ hybridization (FISH) in gastric adenocarcinoma (GAC) and sought its correlation with conventional clinicopathologic parameters. Dual-coloured FISH was done on 32 GAC cases. C-MET gene and centromere 7 signals were counted under fluorescent microscope and ratio was calculat...
Source: Indian Journal of Pathology and Microbiology - December 31, 2019 Category: Pathology Authors: Jain P, Wadhwa N, Joshi MK, Jain M, Halder A, Mishra K Tags: Indian J Pathol Microbiol Source Type: research

Nitric oxide and cancer: a review
Nitric oxide (NO), is a ubiquitous, water soluble, free radical gas, which plays key role in various physiological as well as pathological processes. Over past decades, NO has emerged as a molecule of interest in carcinogenesis and tumor growth progression. However, there is considerable controversy and confusion in understanding its role in cancer biology. It is said to have both tumoricidal as well as tumor promoting effects which depend on its timing, location, and concentration. NO has been suggested to modulate different cancer-related events including angiogenesis, apoptosis, cell cycle, invasion, and metastasis. On ...
Source: World Journal of Surgical Oncology - May 30, 2013 Category: Cancer & Oncology Authors: Sheetal Korde ChoudhariMinal ChaudharySachin BagdeAmol GadbailVaishali Joshi Source Type: research

Most common 'sporadic' cancers have a significant germline genetic component
Common cancers have been demarcated into ‘hereditary’ or ‘sporadic’ (‘non-hereditary’) types historically. Such distinctions initially arose from work identifying rare, highly penetrant germline mutations causing ‘hereditary’ cancer. While rare mutations are important in particular families, most cases in the general population are ‘sporadic’. Twin studies have suggested that many ‘sporadic’ cancers show little or no heritability. To quantify the role of germline mutations in cancer susceptibility, we applied a method for estimating the importance of c...
Source: Human Molecular Genetics - October 21, 2014 Category: Genetics & Stem Cells Authors: Lu, Y., Ek, W. E., Whiteman, D., Vaughan, T. L., Spurdle, A. B., Easton, D. F., Pharoah, P. D., Thompson, D. J., Dunning, A. M., Hayward, N. K., Chenevix-Trench, G., Q-MEGA and AMFS Investigators, ANECS-SEARCH{ddagger}, UKOPS-SEARCH{ddagger}, BEACON Conso Tags: ASSOCIATION STUDIES ARTICLES Source Type: research

The in vitro and vivo effects of nuclear and cytosolic parafibromin expression on the aggressive phenotypes of colorectal cancer cells: a search of potential gene therapy target.
Authors: Zheng HC, Liu JJ, Li J, Wu JC, Yang L, Zhao GF, Zhao X, Jiang HM, Huang KQ, Li ZJ Abstract Down-regulated parafibromin is positively linked to the pathogenesis of parathyroid, lung, breast, ovarian, gastric and colorectal cancers. Here, we found that wild-type (WT) parafibromin overexpression suppressed proliferation, tumor growth, induced cell cycle arrest and apoptosis in colorectal cancer cells (p<0.05), but it was the converse for mutant-type (MT, mutation in nucleus localization sequence) parafibromin (p<0.05). Both WT and MT transfectants inhibited migration and invasion, and caused better diff...
Source: Oncotarget - February 24, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

The search, coagulation, and clipping (SCC) method prevents delayed bleeding after gastric endoscopic submucosal dissection
ConclusionsOur findings suggest that the SCC method is a simple, safe, and effective approach for preventing delayed bleeding after gastric ESD.
Source: Gastric Cancer - September 28, 2018 Category: Gastroenterology Source Type: research

Correction to: The search, coagulation, and clipping (SCC) method prevents delayed bleeding after gastric endoscopic submucosal dissection
The article “The search, coagulation, and clipping (SCC) method prevents delayed bleeding after gastric endoscopic submucosal dissection”, written by Motoi Azumi, Manabu Takeuchi, Youhei Koseki, Masaru Kumagai, Yoko Kobayashi, Masafumi Takatsuna, Aiko Yoshioka, Seiichi Yoshikawa, Tsutomu Miura, and Shuji Te rai, was originally published electronically on the publisher’s internet portal (currently SpringerLink) on 28 September 2018 without open access.
Source: Gastric Cancer - April 23, 2019 Category: Gastroenterology Source Type: research

Cancers, Vol. 15, Pages 900: Primary Tumor Resection for Metastatic Colorectal, Gastric and Pancreatic Cancer Patients: In Search of Scientific Evidence to Inform Clinical Practice
anluca Masi Giuseppe Aprile The management of the primary tumor in metastatic colorectal, gastric and pancreatic cancer patients may be challenging. Indeed, primary tumor progression could be associated with severe symptoms, compromising the quality of life and the feasibility of effective systemic therapy, and might result in life-threatening complications. While retrospective series have suggested that surgery on the primary tumor may confer a survival advantage even in asymptomatic patients, randomized trials seem not to definitively support this hypothesis. We discuss the evidence for and against primary tumor re...
Source: Cancers - January 31, 2023 Category: Cancer & Oncology Authors: Valentina Fanotto Francesca Salani Caterina Vivaldi Mario Scartozzi Dario Ribero Marco Puzzoni Francesco Montagnani Francesco Leone Enrico Vasile Maria Bencivenga Giovanni De Manzoni Debora Basile Lorenzo Fornaro Gianluca Masi Giuseppe Aprile Tags: Review Source Type: research

US recession saw more Google stress searches
Conclusion This research found that there were increased Google searches during the US "Great Recession" between December 2008 and 2011 for a range of health concerns, including headaches, stomach ulcers and other stomach problems, chest pain, heart rhythm problems and various other pains, including back pain and toothache. The researchers consider that this could potentially indicate worsening population health. However, although this is an interesting approach, it is limited by several factors. A person may search Google for information on a health complaint for many different reasons. It does not necessarily ...
Source: NHS News Feed - January 10, 2014 Category: Consumer Health News Tags: Lifestyle/exercise Mental health Medical practice Source Type: news

Evaluating the Impact of the U.S. National Toxicology Program: A Case Study on Hexavalent Chromium
Conclusions: This study identified a broad and objective approach for assessing NTP’s effectiveness, including methodological needs for more thorough and efficient impact assessments in the future. Citation: Xie Y, Holmgren S, Andrews DMK, Wolfe MS. 2017. Evaluating the impact of the U.S. National Toxicology Program: a case study on hexavalent chromium. Environ Health Perspect 125:181–188; http://dx.doi.org/10.1289/EHP21 Address correspondence to Y. Xie, National Institute of Environmental Health Sciences, P.O. Box 12233, Mail Drop K2-03, Research Triangle Park, NC 27709 USA. Express mail address: 530 Davis Dr., Room...
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles February 2017 Source Type: research

Expressivity of Interleukin-8 and Gastric Cancer Prognosis Susceptibility: A Systematic Review and Meta-Analysis
CONCLUSION: High IL-8 expression could be a negative prognostic biomarker for patients with GC.PMID:34531708 | PMC:PMC8438942 | DOI:10.1177/15593258211037127
Source: Dose Response - September 17, 2021 Category: Drugs & Pharmacology Authors: Zhenzhen Wang Yuhan Hou Zhen Yao Yanyan Zhan Wenyue Chen Yulong Liu Source Type: research